Rana P Singh Selected Research

Grape Seed Extract

7/2011	Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells.
7/2010	Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats.
1/2010	Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice.
6/2007	Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice.
10/2006	Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells.
7/2006	Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells.
5/2004	Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells.
2/2004	Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3.
11/2002	Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release.

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Rana P Singh Research Topics

Disease

87	Neoplasms (Cancer) 01/2022 - 03/2002
29	Prostatic Neoplasms (Prostate Cancer) 12/2021 - 06/2002
28	Carcinoma (Carcinomatosis) 12/2021 - 06/2002
21	Carcinogenesis 10/2012 - 08/2002
14	Body Weight (Weight, Body) 03/2018 - 01/2004
9	Adenocarcinoma 01/2020 - 11/2003
9	Skin Neoplasms (Skin Cancer) 01/2018 - 03/2002
9	Colorectal Neoplasms (Colorectal Cancer) 05/2014 - 10/2006
7	Breast Neoplasms (Breast Cancer) 06/2021 - 05/2004
7	Lung Neoplasms (Lung Cancer) 04/2019 - 06/2006
7	Hypoxia (Hypoxemia) 09/2015 - 09/2006
6	Neoplasm Metastasis (Metastasis) 01/2018 - 06/2003
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2019 - 05/2003
4	Papilloma (Papillomatosis) 01/2008 - 03/2002
3	Stomach Neoplasms (Stomach Cancer) 01/2020 - 01/2017
3	Inflammation (Inflammations) 08/2019 - 09/2005
3	Urinary Bladder Neoplasms (Bladder Cancer) 01/2008 - 12/2003
3	Sunburn 08/2005 - 08/2004
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/2005 - 03/2002
2	Glioma (Gliomas) 01/2019 - 09/2003
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 09/2018 - 06/2018
2	Aberrant Crypt Foci 07/2010 - 10/2008
2	Polyps 03/2010 - 12/2009
2	Intestinal Polyps 01/2010 - 12/2009
2	Colonic Neoplasms (Colon Cancer) 01/2010 - 11/2003
2	Prostatic Intraepithelial Neoplasia 12/2008 - 11/2007
2	Retinoblastoma (Glioblastoma, Retinal) 07/2005 - 09/2004

Drug/Important Bio-Agent (IBA)

51	Silybin (Lagosa)IBA 01/2017 - 03/2002
17	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2013 - 09/2003
13	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2003
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 09/2003
9	PhytochemicalsIBA 08/2019 - 05/2002
9	Proliferating Cell Nuclear Antigen (PCNA)IBA 02/2014 - 03/2002
9	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 10/2012 - 06/2006
9	Grape Seed ExtractIBA 07/2011 - 11/2002
8	FlavonoidsIBA 08/2019 - 06/2002
8	Phytic Acid (Inositol Hexaphosphate)IBA 02/2009 - 03/2003
8	SilymarinIBA 12/2008 - 03/2002
7	Biological ProductsIBA 01/2016 - 03/2002
6	fisetinIBA 05/2021 - 02/2012
6	Cyclin-Dependent Kinases (cdk Proteins)IBA 08/2019 - 11/2003
6	AndrogensIBA 10/2014 - 11/2002
6	NF-kappa B (NF-kB)IBA 07/2010 - 09/2003
6	CarcinogensIBA 12/2007 - 08/2002
5	AntioxidantsIBA 03/2018 - 06/2002
5	EnzymesIBA 03/2018 - 01/2005
5	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2017 - 11/2002
5	CyclinsIBA 01/2017 - 03/2003
5	flavanoneIBA 01/2015 - 12/2003
5	beta CateninIBA 07/2010 - 12/2009
5	Transcription Factors (Transcription Factor)IBA 07/2008 - 09/2004
5	CaspasesIBA 11/2006 - 11/2002
5	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 05/2005 - 03/2002
4	Pharmaceutical PreparationsIBA 11/2018 - 11/2002
4	Drinking WaterIBA 01/2018 - 12/2007
4	Antineoplastic Agents (Antineoplastics)IBA 01/2016 - 02/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2012 - 08/2002
4	CytokinesIBA 10/2012 - 07/2008
4	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 10/2012 - 06/2006
4	Cyclin D1IBA 01/2010 - 06/2006
4	Insulin-Like Growth Factor Binding Protein 3IBA 12/2007 - 09/2003
3	DNA (Deoxyribonucleic Acid)IBA 11/2020 - 01/2005
3	ArsenicIBA 01/2018 - 06/2011
3	acacetinIBA 01/2017 - 04/2005
3	Cytochromes c (Cytochrome c)IBA 01/2016 - 11/2002
3	Caspase 3 (Caspase-3)IBA 02/2014 - 09/2004
3	AzoxymethaneIBA 09/2010 - 10/2008
3	Matrix Metalloproteinases (MMPs)IBA 12/2008 - 09/2006
3	SurvivinIBA 01/2008 - 12/2003
3	Phosphotransferases (Kinase)IBA 11/2006 - 09/2004
3	Insulin-Like PeptidesIBA 02/2004 - 06/2002
3	milk-thistle extractIBA 12/2003 - 06/2002
2	Cadherins (E-Cadherin)IBA 12/2021 - 12/2008
2	VimentinIBA 12/2021 - 12/2008
2	Messenger RNA (mRNA)IBA 05/2021 - 12/2003
2	Insulin (Novolin)FDA Link 01/2021 - 09/2010
2	usnic acidIBA 01/2020 - 01/2013
2	ResveratrolIBA 01/2020 - 11/2005
2	BerberineIBA 08/2019 - 02/2014
2	ZincIBA 01/2019 - 01/2005
2	Gallic AcidIBA 03/2018 - 07/2006
2	AnthracyclinesIBA 01/2017 - 12/2004
2	AlkaloidsIBA 01/2016 - 02/2014
2	Tyrosine (L-Tyrosine)FDA Link 10/2013 - 11/2005
2	matrigelIBA 10/2013 - 02/2004
2	Urethane (Ethyl Carbamate)IBA 02/2011 - 06/2006
2	NestinIBA 02/2011 - 01/2009
2	Glycogen Synthase (Synthase I)IBA 09/2010 - 12/2009
2	Sunscreening Agents (Sunscreens)IBA 04/2007 - 09/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2005 - 08/2002
2	Cytotoxins (Cytolysins)IBA 09/2005 - 05/2004
2	Mitogen-Activated Protein KinasesIBA 07/2004 - 03/2002
2	Hormones (Hormone)IBA 02/2004 - 01/2004
1	Small Interfering RNA (siRNA)IBA 12/2021
1	RNA (Ribonucleic Acid)IBA 06/2021
1	diallyl trisulfideIBA 06/2021

Therapy/Procedure

20	Chemoprevention 01/2016 - 01/2004
10	Therapeutics 01/2021 - 08/2002
3	Drug Therapy (Chemotherapy) 01/2016 - 05/2004
3	Radiotherapy 12/2015 - 11/2011